Educational content prepared by Regenérate
The paracrine effect
Studies suggest that much of the benefit of mesenchymal stem cells comes from their paracrine actions: the release of membrane vesicles called exosomes and other bioactive factors that regulate inflammatory and immune processes.
What are exosomes?
They are vesicles that contain proteins and RNA and act as carriers of information between cells. Some laboratories select them by size (50–150 nm) using tangential flow ultrafiltration and offer them for intravenous, intra-articular, intradermal or nebulized administration.
And the secretome?
It is the medium collected while mesenchymal cells are cultured: rich in growth factors, cytokines, chemokines and exosomes. In cosmetics it is encapsulated in PLGA nanocapsules so the active ingredients are released gradually into the skin or scalp.
Common applications
- Facial rejuvenation with microneedling.
- Hair loss: supporting inactive hair follicles.
- Respiratory support through nebulization.
- Wound healing and skin care.
This content is for informational purposes only and does not replace evaluation by a health professional. It has not been evaluated by the FDA.
