Educational content prepared by Regenérate
A growing body of research is studying mesenchymal stromal cells (MSCs) in a range of conditions. These are some of the areas investigated, organized by the tissue the cells come from.
Adipose tissue
- Dermal wound repair.
- Spinal cord injuries.
- Osteoporosis.
- Cartilage and tendon regeneration.
- Metabolic disorders.
Dental pulp
- Dental tissue regeneration.
- Immunomodulation and anti-inflammatory effects.
- Neurodegenerative diseases.
Placental tissue
- Liver damage.
- Therapeutic angiogenesis.
- Critical limb ischemia.
Umbilical cord
- Spinal cord injuries.
- Rheumatoid arthritis.
- Cardiovascular diseases.
- Amyotrophic lateral sclerosis.
Wharton’s jelly
- Diabetes.
- Pulmonary fibrosis.
- Alopecia areata.
- Chronic spinal cord injury.
Bone marrow, amniotic fluid and endometrium
- Bone and wound regeneration.
- Neurological diseases.
- Intrauterine adhesions and ovarian failure.
Despite encouraging results, many of these uses are still under investigation, and the outcome of any cell-based treatment can vary with the stage of the disease and each patient’s individual response.
References
- Zomer, H. D. et al. (2020). Cytotherapy, 22(5), 247–260. doi:10.1016/j.jcyt.2020.02.003
- Liau, L. L. et al. (2020). Treatment of spinal cord injury with mesenchymal stem cells. Cell Biosci 10, 112.
- Jiang, Y. et al. (2021). Advances in MSC transplantation for the treatment of osteoporosis. Cell Proliferation, 54(1).
- Lv, X. et al. (2021). Umbilical cord MSC therapy for rheumatoid arthritis. Drug Des Devel Ther, 15, 3927–3936.
- Kamal, M. M. & Kassem, D. H. (2020). Wharton’s jelly MSCs for diabetes. Front Cell Dev Biol, 8.
- Saleh, M. et al. (2022). Wharton jelly MSCs in pulmonary fibrosis. Stem Cell Res Ther 13, 71.
- Czarnecka, A. et al. (2021). Wharton’s jelly MSCs in alopecia areata. Adv Clin Exp Med, 30(2), 211–218.
- Shirbaghaee, Z. et al. (2023). Phase 1 trial of placental MSCs in critical limb ischemia. Stem Cell Res Ther 14, 174.
This content is for informational purposes only and does not replace evaluation by a health professional. It has not been evaluated by the FDA.
